Signatures of native-like glycosylation in RNA replicon-derived HIV-1 immunogens

Himanshi Chawla; Jacob Willcox; Grace M. Hayes; Murillo Silva; Wen-Hsin Lee; Gabriel Ozorowski; John Butler; Paul F. McKay; Robin J. Shattock; Andrew Ward; Darrell J. Irvine; Max Crispin

doi:10.1039/d5cb00165j

January 1, 2025RSC Chemical BiologyOpen Access

Signatures of native-like glycosylation in RNA replicon-derived HIV-1 immunogens

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Key Points

The study aims to explore glycosylation signatures of RNA replicon-derived HIV-1 immunogens.
Analyzed glycosylation patterns in RNA replicon-derived immunogens
Evaluated effects on vaccine design and efficacy
Identified specific glycosylation signatures associated with immunogens
Demonstrated potential improvements in HIV vaccine design

Implication

Research shows glycosylation patterns of immunogens influence HIV vaccine design, suggesting potential efficacy improvements.

Abstract

RNA-based vaccines have emerged as a highly effective delivery platform. However, this approach eliminates the possibility for immunogen purification, common in manufacturing of recombinant immunogens. In HIV-1 vaccine design, this...

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Cite This Study

Chawla et al. (2025) studied this question.

synapsesocial.com/papers/6966e72c13bf7a6f02bff9a3 https://doi.org/10.1039/d5cb00165j

View Full Paper

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Signatures of native-like glycosylation in RNA replicon-derived HIV-1 immunogens

Key Points

Implication

Abstract

Discussion

Cite This Study

Signatures of native-like glycosylation in RNA replicon-derived HIV-1 immunogens

Key Points

Implication

Abstract

Discussion

Cite This Study

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