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The aim is to design an effective mRNA vaccine targeting the Env region of HIV to stimulate immune responses.

June 27, 2026Scientific ReportsOpen Access

Development of an Env based HIV mRNA vaccine through immunoinformatics and computational modeling

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The aim is to design an effective mRNA vaccine targeting the Env region of HIV to stimulate immune responses.
Utilized various servers and filtering algorithms to select B-cell and T-cell epitopes.
Identified 17 suitable epitopes for inclusion in the vaccine.
Optimized codons and cloned them into prokaryotic vectors to enhance expression.
The vaccine has 364 amino acids with a theoretical isoelectric point of 8.98 and GRAVY score of -0.865.
Molecular dynamics simulations showed highest binding affinity for TLR3 at -318.19 kj/mol.
Ramachandran plot analysis indicated 87.7% of residues in allowed regions, suggesting good stability.

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Randomized trial designs an mRNA vaccine for HIV that targets immune responses, indicating potential for healthcare improvement.

Zubair et al. (2026) studied this question.

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