P-2174. Development and Validation of the Y.E.L.L.O.W. Score: a Novel Prognostic Model for Yellow Fever-Related Acute Liver Failure

Abstract Background A 2017-2018 Yellow Fever (YF) outbreak in southeastern Brazil saw several cases develop acute liver failure (ALF), emphasizing the importance of prognostic tools. Current scoring systems guide treatment and liver transplant decisions, but their use in YF-related ALF is uncertain. This study presents the Y.E.L.L.O.W. Score (Yellow Fever End-stage Liver and Organ Worsening Score) for estimating death probability in YF patients with ALF.Table 1Logistic regression models for the Y.E.L.L.O.W. Score to predict death due to yellow fever.Logistic regression models for the Y.E.L.L.O.W. Score to predict death due to yellow fever.Figure 1QR code linking to a spreadsheet that calculates mortality probability using one of the three Y.E.L.L.O.W. Score logistic regression equations.QR code linking to a spreadsheet that calculates mortality probability using one of the three Y.E.L.L.O.W. Score logistic regression equations. Methods Data from 229 YF patients (confirmed by serology/PCR, age 18) admitted to a reference hospital in Minas Gerais, Brazil (Jan 2017-Mar 2018) were used to develop the Y.E.L.L.O.W. Score. Demographic data, in-hospital mortality, and lab results at 24, 36, and 48 hours were analyzed to estimate death risk. Logistic regression models assessed the Y.E.L.L.O.W. Score's predictive performance.Figure 2Examples demonstrating the use of the spreadsheet to calculate mortality probability with the Y.E.L.L.O.W. Score logistic regression equations.Examples demonstrating the use of the spreadsheet to calculate mortality probability with the Y.E.L.L.O.W. Score logistic regression equations.Figure 3ROC (Receiver Operating Characteristic) curves evaluating the predictive performance of the three logistic regression Y.E.L.L.O.W. Score models.ROC (Receiver Operating Characteristic) curves evaluating the predictive performance of the three logistic regression Y.E.L.L.O.W. Score models. Results Of 229 patients, 197 (86%) were male; median age was 47 (range: 18-82, SD: 13.4). Median time to hospitalization from symptom onset was 4 days (range: 0-40). Bleeding occurred in 41 patients (17.9%), and sepsis in 6 (2.6%). Transfusions were given to 64 (27.9%), and 26 (11.4%) needed dialysis. Multivariate analysis included: age, encephalopathy grade, hemoglobin, platelets, leukocytes, neutrophils, INR (International Normalized Ratio), AST (aspartate transaminase), direct bilirubin, creatinine, and lactate. Logistic regression identified 6 risk factors and 1 protective factor for YF death. To maintain consistency across time points (24, 36, and 48 hours post-admission), 7 variables were kept in models, even without significance (Table 1). Mortality probability is estimated from logistic regression models (QR code in Fig. 1). Fig. 2 shows spreadsheet examples for Y.E.L.L.O.W. Score mortality probability. All 3 models highly predict YF death (Fig. 3). Conclusion This study developed and validated the Y.E.L.L.O.W. Score, a novel method for estimating death probability in yellow fever patients with acute liver failure. The score uses readily available clinical and laboratory data from 24, 36, and 48 hours post-admission. Logistic regression models show high predictive ability, suggesting the Y.E.L.L.O.W. Score is a valuable tool for clinicians in assessing prognosis and guiding management of yellow fever-related acute liver failure. Disclosures All Authors: No reported disclosures