A highly sensitive LC-MS/MS method for quantification of AB-38b in rat plasma, liver and kidney tissues: application to a pharmacokinetic study

Key Points

• To develop a highly sensitive method for quantifying AB-38b in biological samples.
• Developed an LC-MS/MS method to quantify AB-38b in rat plasma, liver, and kidney tissues.
• Applied this method to a pharmacokinetic study in a rat model.
• Validated the sensitivity of LC-MS/MS for measuring AB-38b levels in various tissues.
• Results indicated possible implications for understanding diabetic kidney disease pathophysiology.