Hydrogen-bond-assisted meta-nitrogen-doped graphyne enables real-time electrocatalytic NADH tracking in single cells

Key Points

• This research aims to track NADH levels in single cells using meta-nitrogen-doped graphyne.
• Utilized hydrogen-bond-assisted meta-nitrogen-doped graphyne for sensing
• Monitored real-time NADH levels as an indicator of mitochondrial health
• Analyzed the roles of α-synuclein and Ca 2+ in cellular processes.
• Demonstrated real-time tracking of NADH in individual cells
• Showed that α-synuclein clustering correlates with increased NADH levels
• Indicated a link between mitochondrial failure and neurodegeneration.