Electrocatalytic NADH tracking reveals α-synuclein clustering and neurodegeneration in single cells, indicating mitochondrial dysfunction.
MPP + drives α-synuclein to cluster, Ca 2+ to surge and mPTP to open, triggering NADH release. 3NGYO/CFNE senses NADH through N–H⋯OP bonds for real-time reporting of mitochondrial failure and neurodegeneration.
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Wei et al. (2026) studied this question.
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