ABSTRACT Objective Mandibular retrognathism (MR) is a skeletal malocclusion in which patients have a deficient mandibular length, resulting in a more posterior position of the mandible. We aimed to investigate the association between Single nucleotide polymorphisms (SNPs) in Fibroblast Growth Factor Receptor 2 ( FGFR2) gene and MR in germans. Materials and Methods Genomic DNA and lateral cephalometric radiographs were obtained from orthodontic patients. Patients were allocated into the ‘Retruded’ group (SNB angle < 78°) and into the ‘Well‐positioned’ group (SNB 78°–82°). The rs4752566, rs10736303, rs11200014, rs1078806, rs1219648, rs2981578 and rs2162540 SNPs were genotyped using real‐time PCR. Allele, genotype and haplotype frequencies were compared (α = 5%). Results A total of 142 patients were included, 93 (65.5%) allocated into the ‘Retruded’ group and 49 (34.5%) into the ‘Well‐positioned’ group. The allele T in rs2981578 SNP was statistically more frequent in the ‘Retruded’ group in both univariate (PR = 1.22; 95% CI, = 1.02–1.47) and multivariate (PR = 1.55; 95% CI, = 1.07–2.25) analyses ( p < 0.05). The CT + TT genotypes were statistically more frequent in the ‘Retruded’ group in univariate (PR = 1.58; 95% CI, = 1.03–2.41) and multivariate (PR = 1.59; 95% CI, = 1.11–2.26) analysis ( p < 0.05). All studied SNPs were associated with MR establishment in haplotype analysis ( p < 0.05). Conclusion SNPs in the FGFR2 are associated with MR and have the potential to serve as genetic biomarkers to early diagnosis and prediction of mandible growth.
Reis et al. (Mon,) studied this question.