What question did this study set out to answer?

To investigate the association between SNPs in the FGFR2 gene and mandibular retrognathism (MR) in Germans.

Intronic Single Nucleotide Polymorphisms in FGFR2 Gene Association With Non‐Syndromic Mandibular Retrognathism

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To investigate the association between SNPs in the FGFR2 gene and mandibular retrognathism (MR) in Germans.
Collected genomic DNA and lateral cephalometric radiographs from orthodontic patients.
Divided patients into 'Retruded' and 'Well‐positioned' groups based on SNB angle.
Genotyped SNPs using real‐time PCR and compared allele, genotype, and haplotype frequencies.
142 patients total: 93 in 'Retruded' group and 49 in 'Well‐positioned' group.
The T allele in rs2981578 SNP was more frequent in the 'Retruded' group (PR = 1.22; p < 0.05).
CT + TT genotypes were more frequent in the 'Retruded' group (PR = 1.58; p < 0.05).
All SNPs studied showed association with MR in haplotype analysis (p < 0.05).

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Analysis reveals associations of FGFR2 SNPs with mandibular retrognathism, suggesting genomic DNA markers for early diagnosis.

Reis et al. (2026) studied this question.

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