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P-560. The Genomic Epidemiology of Fulminant Streptococcus pyogenes Infections in Rochester, NY: Why Community Surveillance Matters

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To investigate the genetic relatedness of fulminant Streptococcus pyogenes infections among patients and healthcare workers.
Contact tracing and testing of healthcare workers with close patient contact were conducted.
Whole genome sequencing was performed on isolated bacteria.
Medical records were reviewed retrospectively and prospectively.
Genetic relatedness was assessed among collected isolates.
40 isolates from 36 patients and one positive healthcare worker were collected and clustered into 13 lineages.
Isolates showed no temporal or epidemiologic connections, despite being related genetically.
The index isolate was identified as ST-15 emm 3.1, with virulence genes correlating to strain types.

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Observational study evaluates genomic relatedness of fulminant infections in healthcare workers, suggesting community surveillance is crucial.

Fnu et al. (2026) studied this question.

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Observational study evaluates genomic relatedness of fulminant infections in healthcare workers, suggesting community surveillance is crucial.