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January 14, 2026Open Forum Infectious DiseasesOpen Access

P-656. Epidemiology of Mycoplasma pneumoniae Infections after COVID-19 Pandemic

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Authors

LMLakshmi MarimuthuJohns Hopkins UniversityAPAndy PekoszJohns Hopkins UniversityASAnna Sick-SamuelsJohns Hopkins University

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Implication

Retrospective cohort revealed pneumonia cases surged in children post COVID-19, highlighting macrolide resistance.

Key Points

  • This research aims to describe the clinical characteristics and macrolide resistance of Mycoplasma pneumoniae infections in 2023-2024.
  • Conducted a retrospective cohort study of M. pneumoniae infections at a Maryland hospital system.
  • Analyzed Electronic Health Records of patients diagnosed with M. pneumoniae using RPP and IgM tests.
  • Excluded patients without consistent clinical symptoms or alternative diagnoses.
  • Performed genetic analysis of resistance using nanopore sequencing.
  • Identified 431 patients, 377 (87.5%) diagnosed via RPP.
  • Found that 44.8% of patients were hospitalized, and 30.5% required respiratory support.
  • Discovered 26.1% of tested RPPs had genetic polymorphism associated with macrolide resistance.

Cite This Study

Marimuthu et al. (2026) studied this question.

synapsesocial.com/papers/6966f2f013bf7a6f02c0055bhttps://doi.org/10.1093/ofid/ofaf695.869
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1P-460. Clinical Presentations and Outcomes of Pediatric Mycoplasma pneumoniae: A Retrospective Chart Review2026
  2. 2A-287 <i>Mycoplasma pneumoniae</i> outbreak in 2023: Post pandemic resurgence of an atypical bacterial pathogen2024
  3. 3Mycoplasma pneumoniae infection outbreak in Guangzhou, China after COVID-19 pandemic2024 · 43 citations
  4. 4Multicenter analysis of the Mycoplasma pneumoniae resurgence in China 2023–20242025 · 8 citations
  5. 5Post-COVID-19 Pandemic Rebound of Macrolide-Resistant Mycoplasma pneumoniae Infection: A Descriptive Study2024 · 33 citations