In synergy with interferon‐gamma, interleukin‐17 activates vascular stromal cells towards a pro‐inflammatory profile in giant cell arteritis

This is a In Vitro Study study.

Key Points

This research examines the role of IL‐17 in giant cell arteritis and its impact on vascular inflammation.
Cultured temporal artery biopsies in MATRIGEL® with IL‐17, secukinumab, or control IgG.
Analyzed samples using bulk RNA‐sequencing and RT‐qPCR.
Compared positive TABs with GCA features to negative TABs and studied cultures of myofibroblasts.
Utilized confocal microscopy for IL‐17 receptor expression analysis.
Secukinumab reduced expression of vascular inflammation-related genes in positive TABs.
IL‐17 increased cytokines like IL‐6 and GM‐CSF in myofibroblasts, reversed by secukinumab.
IL‐17 receptor chains were enhanced by interferon‐gamma, promoting T‐cell polarization.

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Finds IL‐17 drives vascular inflammation in giant cell arteritis, suggesting a role for myofibroblasts and cytokines.

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Greigert et al. (2026) studied this question.

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