What question did this study set out to answer?

This study evaluates the long-term efficacy, safety, and tolerability of DTG+3TC as a switch regimen.

January 14, 2026Open Forum Infectious DiseasesOpen Access

P-353. Ten Years Results on the Effectiveness and Safety of DTG+3TC as a Switch Regimen in a Multicenter Cohort

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Authors

GBGianmaria Baldin EZEnea ZiniFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico ACAdriana Cervo

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Implication

Observational study shows high efficacy and safety of DTG+3TC in 2430 PLWH, suggesting favorable outcomes in virological suppression and tolerability.

Key Points

This study evaluates the long-term efficacy, safety, and tolerability of DTG+3TC as a switch regimen.
Observational study involving 2430 virologically suppressed PLWH
Kaplan-Meyer survival analysis for virological failure and treatment discontinuation
Cox-regression analysis for predictors of failure and discontinuation
Assessment of immunological and metabolic changes using linear mixed models
82 virological failures observed (0.9 per 100 PYFU) with no emergent resistance mutations
Probabilities of maintaining virological suppression at 240 and 480 weeks were 96.2% and 92.8%, respectively
339 treatment discontinuations noted (3.7 per 100 PYFU), with CNS toxicity being a common reason
Significant improvement in CD4+ count and CD4/CD8 ratio after 240 weeks
Improvement in total cholesterol, triglycerides, and HDL cholesterol at both 240 and 480 weeks

Cite This Study

Baldin et al. (2026) studied this question.

synapsesocial.com/papers/6966f2fb13bf7a6f02c005cd https://doi.org/10.1093/ofid/ofaf695.571

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Implication

Observational study shows high efficacy and safety of DTG+3TC in 2430 PLWH, suggesting favorable outcomes in virological suppression and tolerability.

P-353. Ten Years Results on the Effectiveness and Safety of DTG+3TC as a Switch Regimen in a Multicenter Cohort

Discussion

Member takes

Implication

Key Points

Cite This Study

P-353. Ten Years Results on the Effectiveness and Safety of DTG+3TC as a Switch Regimen in a Multicenter Cohort

Discussion

Member takes

Implication

Key Points

Cite This Study

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