Abstract Objective To define survival and recurrence outcomes of HPV associated oropharyngeal squamous cell carcinoma (OPSCC) following transoral robotic surgery (TORS). Data Sources PubMed, Scopus, CINAHL. Review Methods A systematic review and meta‐analysis were performed on studies employing TORS in HPV‐associated OPSCC. Meta‐analysis of continuous measures, proportions, and comparison of weighted proportion and relative risk were performed for patient characteristics and outcomes. Results A total of 58 studies, comprising 16,129 adults treated with TORS for OPSCC, were included. The mean age was 59.5 years (SD 2.08) (range 18‐93), with an average follow‐up of 43.4 months (SD 13.36); 83.5% of the cohort was male, and 85.6% had HPV‐positive OPSCC. In the HPV‐positive group, TORS survival rates were 91.0% at 1 year, 94.9% at 3 years, and 89.8% at 5 years. In comparison, the HPV‐negative group had survival rates of 92.3%, 84.2%, and 72.9%, respectively. Significant survival differences were observed between cohorts at 3 and 5 years ( P < .0001). The HPV‐positive group had a significantly higher likelihood of 5‐year overall survival compared to the HPV‐negative group (RR = 1.18, 95% CI: 1.05‐1.34) Recurrence rates in HPV‐positive patients were 2.0% local, 3.1% regional, and 5.3% locoregional, whereas HPV‐negative patients had recurrence rates of 7.6% local, 6.0% regional, and 9.1% locoregional ( P = .0037, .2143, .426, respectively). Distant metastasis rates were 5.6% in HPV‐positive and 10.2% in HPV‐negative patients ( P = .0033). Conclusion The higher survival rates and lower recurrences in HPV‐positive OPSCC patients compared to their HPV‐negative counterparts reflects the favorable long‐term oncologic outcome seen in HPV‐associated OPSCC.
Cheung et al. (Mon,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: