What type of study is this?

This is a In Vitro Study study.

What question did this study set out to answer?

To evaluate the in vitro activity of cefiderocol against carbapenem-nonS Acinetobacter baumannii-calcoaceticus complex isolates.

January 14, 2026Open Forum Infectious DiseasesOpen Access

P-1286. In vitro Activity of Cefiderocol against Carbapenem-nonsusceptible Acinetobacter baumannii-calcoaceticus complex, Including Molecularly Characterized Clinical Isolates, Causing Infections in United States Hospitals (2020–2024)

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Authors

RMRodrigo E. MendesJMI Laboratories JMJoshua MaherJMI Laboratories ZKZachary KocklerJMI Laboratories

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Implication

In vitro testing shows cefiderocol effectiveness against multidrug-resistant Acinetobacter, indicating a treatment option for carbapenem-resistant infections.

Key Points

To evaluate the in vitro activity of cefiderocol against carbapenem-nonS Acinetobacter baumannii-calcoaceticus complex isolates.
Collected 1,999 ACB isolates from 76 US hospitals (2020-2024)
Performed susceptibility testing using broth microdilution methods
Screened for β-lactamase genes in resistant isolates
29.4% of isolates were carbapenem-nonS, with carbapenemase genes in 86.4% of those
Cefiderocol showed 92.9-97.7% susceptibility with MIC50 of 0.12 mg/L and MIC90 of 1 mg/L
Limited activity from β-lactam comparators (66.8-72.0% susceptibility)

Cite This Study

Mendes et al. (2026) studied this question.

synapsesocial.com/papers/6966f30613bf7a6f02c00879 https://doi.org/10.1093/ofid/ofaf695.1474

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Implication

In vitro testing shows cefiderocol effectiveness against multidrug-resistant Acinetobacter, indicating a treatment option for carbapenem-resistant infections.

P-1286. In vitro Activity of Cefiderocol against Carbapenem-nonsusceptible Acinetobacter baumannii-calcoaceticus complex, Including Molecularly Characterized Clinical Isolates, Causing Infections in United States Hospitals (2020–2024)

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Key Points

Cite This Study

P-1286. In vitro Activity of Cefiderocol against Carbapenem-nonsusceptible Acinetobacter baumannii-calcoaceticus complex, Including Molecularly Characterized Clinical Isolates, Causing Infections in United States Hospitals (2020–2024)

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