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January 11, 2026Medical Journal of Western Black SeaOpen Access

The correlation between serum YKL-40, proteinuria and inflammation in patients with systemic lupus erythematosus

İlyas Öztürk Fatma Betül Güzel Serhat Kura Enes Süleyman Gün Burak Okyar Sinan Kazan Muhammed Seyithanoğlu Şule Yaşar Bilge Orcun Altunören Özkan Güngör

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Key Points

This study aims to investigate the relationship between YKL-40 levels, proteinuria, and inflammation in patients with systemic lupus erythematosus.
Included 51 patients with systemic lupus erythematosus from the nephrology outpatient clinic.
Conducted blood and urine tests and measured YKL-40 levels using ELISA.
Analyzed correlations between serum YKL-40, proteinuria, and inflammatory markers.
YKL-40 positively correlated with C-reactive protein and erythrocyte sedimentation rate.
Median proteinuria amount was 190 mg/g among participants.
Mean YKL-40 level was reported as 12.9 pg/ml.

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Implication

Investigation finds a significant relationship between YKL-40 levels and proteinuria in lupus patients, suggesting inflammation involvement.

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Cite This Study

Öztürk et al. (2026) studied this question.

synapsesocial.com/papers/6966f30613bf7a6f02c008ff https://doi.org/10.29058/mjwbs.1793565

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