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January 14, 2026Open Forum Infectious DiseasesOpen Access

P-861. Incidence of Methicillin-Resistant Staphylococcus aureus (MRSA) in Sepsis of Unknown Source

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Authors

JFJonah J FarhaSDSara DreilingSHStephanie J. Harding

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Overview

Retrospective study reveals low MRSA rates in sepsis patients with unknown infection source, highlighting risk factors.

Key Points

  • Determine the incidence of MRSA in patients with sepsis of unknown source at Wesley Medical Center.
  • Retrospective incidence study involving adult patients at Wesley Medical Center with sepsis of unknown source in 2023.
  • Patients identified by ICD-10 code A41.9 and evaluated for MRSA cultures and risk factors.
  • Risk factors included history of MRSA, hospitalization, antibiotic use, or surgery within specified time frames.
  • 4,405 patients with sepsis of unknown source admitted in 2023, with 1.7% testing positive for MRSA.
  • 62% of MRSA positive patients had at least one risk factor, most commonly recent hospitalization.
  • 31% of MRSA positive patients had more than one risk factor.

Cite This Study

Farha et al. (2026) studied this question.

synapsesocial.com/papers/6966f32713bf7a6f02c00da9https://doi.org/10.1093/ofid/ofaf695.1069
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Factors Associated with Methicillin-Resistant Staphylococcus aureus Infection Among Patients with Sepsis Presenting to Emergency Departments: A Nationwide Multicenter Cohort Study2026
  2. 2P-27. Methicillin Resistance and Its Effect on Clinical Outcomes in Staphylococcus aureus Bacteremia-Associated Sepsis: A Retrospective Cohort Analysis2026
  3. 3P-1088. Evaluating the Impact of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections on Hospital Outcomes in Northern Jordan: A Retrospective Cohort Study2026
  4. 4Impact of Methicillin Resistance on Outcomes of <i>Staphylococcus aureus</i> Bacteremia at a U.S. Center, 2023–20242026 · 1 citations
  5. 5Ten-year surveillance of antimicrobial susceptibility patterns of Staphylococcus aureus in a tertiary care hospital: a retrospective laboratory-based study2026