What question did this study set out to answer?

To analyze lncRNA expression profiles in serum-derived exosomes related to age-related hearing loss.

January 14, 2026DiagnosticsOpen Access

The Whole Transcriptome Sequencing Profile of Serum-Derived Exosomes and Potential Pathophysiology of Age-Related Hearing Loss

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Systematic analysis identifies key lncRNAs and biomarkers associated with age-related hearing loss, suggesting potential therapeutic targets.

To analyze lncRNA expression profiles in serum-derived exosomes related to age-related hearing loss.
Collected peripheral blood samples from ARHL patients and controls.
Isolated serum exosomes using nanoparticle tracking analysis, electron microscopy, and Western blot.
Performed lncRNA transcriptome sequencing and functional analysis including GO and KEGG.
Identified 2874 differentially expressed lncRNAs, with 988 downregulated and 1886 upregulated.
Detected 2132 differentially expressed mRNAs, with 882 downregulated and 1250 upregulated.
Key biomarkers THAP2, ZNF225, MED12, and RNF141 were validated as candidates for ARHL.

Yang et al. (2026) studied this question.

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Systematic analysis identifies key lncRNAs and biomarkers associated with age-related hearing loss, suggesting potential therapeutic targets.