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January 14, 2026DiagnosticsOpen Access

Biomarkers for Predicting Malignant Transformation of Premalignant Lesions of the Larynx: A Systematic Review

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Authors

JRJuan P. RodrigoRLReydson Alcides De Lima-SouzaFLF. Lopez

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Overview

Systematic review identifies biomarkers predicting malignant transformation of premalignant laryngeal lesions, highlighting patient management implications.

Key Points

  • This work aims to identify biomarkers that predict malignant transformation of premalignant laryngeal lesions to enhance patient management.
  • Conducted a systematic review following PRISMA 2020 guidelines.
  • Searched PubMed, Scopus, Embase, and Google Scholar for relevant studies.
  • Included studies examining biomarkers for histopathologically confirmed premalignant laryngeal lesions.
  • Assessed risk of bias using the ROBINS-I tool.
  • 11 studies met inclusion criteria, involving 730 patients.
  • Identified diverse biomarker categories: protein markers, immune markers, microRNAs, and genetic markers.
  • Most studies showed moderate to serious risk of bias primarily due to limited confounder control.

Cite This Study

Rodrigo et al. (2026) studied this question.

synapsesocial.com/papers/6966f32713bf7a6f02c00f07https://doi.org/10.3390/diagnostics16020236
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