Systematic review analyzes immunohistochemical biomarkers predicting malignant transformation in oral leukoplakia and lichen planus, suggesting clinical implications.
Key Points
Bcl-2 and p53 are significant immunohistochemical markers indicating potential malignant transformation in oral premalignant lesions.
The systematic review analyzed 10 studies with a total of 549 participants focusing on immunohistochemical biomarkers in oral leukoplakia and lichen planus.
Immunohistochemical analysis highlighted the importance of Ki-67 and Bax for understanding cell proliferation and apoptotic balance in these lesions.
A panel of biomarkers, particularly Bcl-2 and p53, shows strong potential for enhancing risk assessment and clinical management for patients with oral leukoplakia and lichen planus.