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June 12, 2026Head & Neck

Malignant Transformation in Oral Lichen Planus and Oral Lichenoid Lesions: A Retrospective Study

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Authors

APAdrien PelletSAScarlette Agbo-GodeauWPWilliam Pouillot

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Overview

Retrospective study shows risk factors for malignant transformation in oral lesions, implying a need for careful monitoring.

Key Points

  • The aim was to investigate the incidence and risk factors associated with malignant transformation in oral lichen planus and related lesions.
  • Retrospective cohort of 188 patients with diagnosed oral lichen planus, oral lichenoid lesions, or oral dysplasia with lichenoid features.
  • Performed uni- and multivariate analysis to evaluate risk factors associated with malignant transformation.
  • Followed patient outcomes for a minimum of 12 months.
  • Malignant transformation was 5.9% for oral lichenoid lesions, 0% for oral lichen planus, and 42.9% for oral dysplasia with lichenoid features.
  • Presence of dysplasia significantly increased the risk of transforming to squamous cell carcinoma (OR = 7.40; p = 0.01).
  • Asymmetry of the lesion was also associated with malignant transformation (OR = 8.81; p = 0.009).

Cite This Study

Pellet et al. (2026) studied this question.

synapsesocial.com/papers/6a2ba3a28101cf8926f023fahttps://doi.org/10.1002/hed.70345
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