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October 2, 2025Oral DiseasesOpen Access

Cancer Hallmarks Expression in Oral Leukoplakia: Systematic Review and Meta‐Analysis

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Authors

IGIsabel González‐RuizPRPablo Ramos‐GarcíaHBHajar Boujemaoui‐Boulaghmoudi

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Overview

Systematic review and meta-analysis reports increased malignant transformation in oral leukoplakia, highlighting cancer hallmarks and oncogenic events.

Key Points

  • Malignant transformation in oral leukoplakia is significantly increased with hyperproliferative lesions, enhancing cancer risk.
  • The hallmark of sustaining proliferation was observed in 56.30% of leukoplakia cases, strongly linked to malignancy with a relative risk of 1.92.
  • Longitudinal cohort studies assessed molecular events in oral leukoplakia, using immunohistochemical techniques for biomarker analysis.
  • Findings suggest that mechanisms like epithelial–mesenchymal transition and immune evasion play crucial roles in oral cancer development.

Cite This Study

González‐Ruiz et al. (2025) studied this question.

synapsesocial.com/papers/68de796d5b556a9128e1acfahttps://doi.org/10.1111/odi.70106
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