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October 1, 2025Journal of Indian Academy of Oral Medicine and RadiologyOpen Access

Malignant Transformation of Oral Leukoplakia – An Umbrella Review

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Authors

SSS. SowmyaUMUma MaheswariPPPreeja Premakumar

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Overview

This umbrella review analyzes malignant transformation rates in oral leukoplakia, focusing on tobacco use and lesion subtype.

Key Points

  • A higher risk of malignant transformation in oral leukoplakia is confirmed, especially for non-homogeneous lesions.
  • The pooled malignant transformation rate ranged from 3.5% to 43.87% across eight systematic reviews involving 95,467 patients.
  • The review systematically analyzed existing systematic reviews up to August 2024, examining various databases for data extraction.
  • Findings indicate that smokeless tobacco use with alcohol consumption significantly increases the risk of malignant transformation.

Cite This Study

Sowmya et al. (2025) studied this question.

synapsesocial.com/papers/68dd91c7fe798ba2fc498670https://doi.org/10.4103/jiaomr.jiaomr_21_25
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Also Consider

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  1. 1Malignant Transformation of Oral Leukoplakia and Proliferative Verrucous Leukoplakia and Its Biomarker Predictors: A Systematic Umbrella Review2025 · 6 citations
  2. 2RETROSPECTIVE ANALYSIS OF ORAL POTENTIALLY MALIGNANT DISEASESAN INSTITUTIONAL EXPERIENCE.2024
  3. 3Malignant Transformation Risk in Patients With Oral Leukoplakia and Type 2 Diabetes Mellitus.2026
  4. 4Cancer Hallmarks Expression in Oral Leukoplakia: Systematic Review and Meta‐Analysis2025 · 4 citations
  5. 5Predicting Malignant Transformation in Oral Leukoplakia: A Multilayer Perceptron Approach Incorporating Clinicopathological Features and <scp>DNA</scp> Content2025