What question did this study set out to answer?

This research aims to compare the virological, immunological, renal, and metabolic outcomes of two antiretroviral regimens in HIV patients.

January 14, 2026Open Forum Infectious DiseasesOpen Access

P-375. Real-World Comparison of BIC/TAF/FTC and DTG/TDF/FTC Regimens in ART-Naive HIV Patients: Virological, Immunological, and Metabolic Outcomes

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This research aims to compare the virological, immunological, renal, and metabolic outcomes of two antiretroviral regimens in HIV patients.
Retrospective observational study
Patients diagnosed with HIV from 2020 to 2024
Assessment of BIC/TAF/FTC versus DTG/TDF/FTC regimens
Follow-up for at least 24 weeks
Comparison of virological suppression, CD4 count, eGFR, lipid profile, and adverse events.
High virological suppression rates in both groups with no significant difference
DTG/TDF/FTC showed 97.6% efficacy in patients with CD4 >200 cells/mm³ vs 42.8% with CD4 <200 cells/mm³
BIC/TAF/FTC showed better CD4 increases, indicating superior long-term immunological response
Higher drug discontinuation due to nephrotoxicity in the DTG/TDF/FTC group
Significant increase in Framingham risk score in BIC/TAF/FTC group over time.

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Implication

Retrospective analysis compares virological suppression and immunological response in ART-naive HIV patients on BIC/TAF/FTC versus DTG/TDF/FTC, suggesting differential long-term outcomes.

Cite This Study

Akcesme et al. (2026) studied this question.

synapsesocial.com/papers/6966f33213bf7a6f02c01009 https://doi.org/10.1093/ofid/ofaf695.593

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Implication

Retrospective analysis compares virological suppression and immunological response in ART-naive HIV patients on BIC/TAF/FTC versus DTG/TDF/FTC, suggesting differential long-term outcomes.

P-375. Real-World Comparison of BIC/TAF/FTC and DTG/TDF/FTC Regimens in ART-Naive HIV Patients: Virological, Immunological, and Metabolic Outcomes

Key Points

Discussion

Implication

Cite This Study

P-375. Real-World Comparison of BIC/TAF/FTC and DTG/TDF/FTC Regimens in ART-Naive HIV Patients: Virological, Immunological, and Metabolic Outcomes

Key Points

Discussion

Implication

Cite This Study

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