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January 14, 2026Food & Function0 citations

Multi-omics reveals gut microbiota-derived taurodeoxycholic acid mediates the protective effect of Lactobacillus rhamnosus GG against LPS-induced liver injury

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PWPeng WangYWYupu WangWGWenting Gao

Key Points

  • This research investigates how gut microbiota influences liver injury through taurodeoxycholic acid.
  • Utilized multi-omics approaches
  • Examined the role of Lactobacillus rhamnosus GG
  • Analyzed the impact of LPS on liver injury
  • Identified taurodeoxycholic acid as a protective mediator
  • Found that Lactobacillus rhamnosus GG prevents liver injury caused by LPS
  • Demonstrated a link between gut microbiota and metabolic syndrome

Abstract

Gut microbiota-derived lipopolysaccharide (LPS) is a critical mediator in the pathogenesis of nonalcoholic fatty liver disease and metabolic syndrome. The liver plays a crucial role in mediating immune responses and...

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6966f33213bf7a6f02c01113https://doi.org/10.1039/d5fo05530j
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