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Systematic analysis reveals dual-mechanism hypothesis and hematological findings in α-thalassemia subtypes, indicating clinical benefits.
Based on this systematic analysis, we proposed a dual-mechanism hypothesis ('functional trigger + linkage maintenance') to explain the Hb Q-Thailand/-α4.2 (B) association. Hematological findings were consistent. These results deepen our understanding of the molecular and clinical characteristics of -α4.2 subtypes, helping clinicians provide more precise counseling.
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Wang et al. (2026) studied this question.
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