Mutational Landscape of Colorectal Tumors From Individuals With Unexplained Adenomatous or Serrated Colorectal Polyposis

Anna K. Sommer; Iris B.A.W. Te Paske; E. Jansen; Axel Gschwind; G E Demidov; Verena Steinke-Lange; Xiaoyu Yin; Wouter Steyaert; Burcu Yaldiz; M. Steehouwer; Oliver Hommerding; Dimo Dietrich; Sophia O Peters; José Garcia‐Pelaez; Andreas Laner; Carla R. P. Oliveira; Capellá Gabriel; Iris D. Nagtegaal; Hendrik Bläker; Kornelia Ellwanger; A. Hoischen; C. Gilissen; Rachel S. van der Post; G Kristiansen; Nicoline Hoogerbrugge; Stephan Ossowski; Laura Valle; E. Holinski-Feder; M. J. L. Ligtenberg; Stefan Aretz; Richarda M. de Voer

doi:10.1053/j.gastro.2025.10.011

Key Points

The study aims to investigate the mutational landscape of colorectal tumors in individuals with unexplained adenomatous or serrated colorectal polyposis.
Molecular tumor profiling of colorectal tumors
Comparison of BRAF, APC, and CTNNB1 mutations
Analysis of tumor similarity to normal colon tissue
BRAF-mutated serrated polyps are closer to normal colon tissue than APC or CTNNB1-mutated tumors
Understanding of genetic disease etiology is enhanced through profiling of polyposis patients

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Implication

Molecular profiling uncovers genetic insights in colorectal tumors, highlighting differences among mutations.

Abstract

Our results indicate that BRAF-mutated serrated polyps are molecularly more similar to normal colon tissue than APC- and/or CTNNB1-mutated tumors. Overall, molecular tumor profiling of individuals with polyposis contributes to understanding the genetic disease etiology.

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Cite This Study

Sommer et al. (2026) studied this question.

synapsesocial.com/papers/696718c687ba607552bb8aab https://doi.org/10.1053/j.gastro.2025.10.011

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Mutational Landscape of Colorectal Tumors From Individuals With Unexplained Adenomatous or Serrated Colorectal Polyposis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Mutational Landscape of Colorectal Tumors From Individuals With Unexplained Adenomatous or Serrated Colorectal Polyposis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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