Key result
Systemic-cybernetic framework defines health as sustained regulatory capacity under perturbation and disease as exceeded capacity.
Why the study?
Many chronic and heterogeneous conditions resist explanation under static or linear frameworks that model biological health solely as stable internal states or absence of structural pathology.
Design
Theoretical framework proposal
Answers are grounded in this paper and cite their sources.
Warrants no change in cardiovascular practice; leaves open empirical validation of regulatory capacity as a clinical framework.
Biological health is commonly modeled as the maintenance of stable internal states or the absence of structural pathology. However, many chronic and heterogeneous conditions resist explanation under static or linear frameworks. This document proposes a systemic-cybernetic framework in which health is defined as sustained regulatory capacity under perturbation, and disease emerges from saturation-driven functional reorganization. Symptoms are treated as system outputs rather than errors, and pathology is understood as a consequence of persistent demand exceeding regulatory capacity across mismatched timescales. The framework emphasizes flow, feedback, hysteresis, and multi-scale regulation, offering falsifiable predictions and a unifying lens across biological, behavioral, and environmental domains.
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Evai (2026) studied this question. The systemic-cybernetic framework defines health as sustained regulatory capacity under perturbation, with disease arising from exceeded regulatory capacity.
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