Abstract Purpose Sepsis‐associated encephalopathy (SAE) is a common neurological complication of sepsis. UMI‐77 has shown unique benefits in modulating inflammation to improve sepsis. However, the exact role of UMI‐77 in the treatment of SAE and its mechanism are unknown. Aim This article analyzes UMI‐77 based on metabolomics and explores its mechanism of action in treating SAE based on the brain‐gut axis. Method In this study, hematoxylin and eosin (H metabolic pathway analysis revealed that these differential metabolites were mainly involved in phenylalanine, tyrosine, and tryptophan biosynthesis, and biotin metabolism. L‐phenylalanine, L‐tyrosine, and 5‐hydroxy‐tryptophan are the most important metabolites. Conclusion UMI‐77 plays a positive regulatory role in disrupting the gut microbiota of mice through pathways such as the biosynthesis of phenylalanine, tyrosine, and tryptophan, and can significantly improve neurological function and reduce apoptosis of brain tissue cells.
Yu et al. (Thu,) studied this question.