Patients with atrial fibrillation showed a higher frequency of the rare G allele (AG + GG genotypes) compared to controls, but this difference was not statistically significant (OR 1.357).
Does the rs3903239 polymorphism of the PRRX1 gene increase the risk of atrial fibrillation in the Kazakh population?
The rs3903239 polymorphism of the PRRX1 gene does not show a statistically significant association with atrial fibrillation in the Kazakh population.
Absolute Event Rate: 0% vs 0%
Background/Objectives. Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and represents a major public health problem. Genetic factors contribute to AF susceptibility, including variants associated with atrial remodeling. Methods. This case–control study investigated the rs3903239 polymorphism of the PRRX1 gene in a Kazakh population. The main group included patients with AF (n = 75), the control group consisted of 2 subgroups: subgroup 1 (control group 1) included conditionally healthy patients (n = 73), subgroup 2 (control group 2) consisted of patients with arterial hypertension (AH) and coronary heart disease (CHD) without diagnosed AF at the time of inclusion in the study (n = 50). Genotype and allele frequencies were compared between patients with AF and two control groups. The frequency of the rs3903239 polymorphism genotypes of the PRRX1 gene in the main group and in the control groups was in the Hardy–Weinberg equilibrium. Results. The frequency of the rare G allele (AG + GG genotypes) was higher in patients with AF compared with conditionally healthy controls; however, this difference did not reach statistical significance (OR 1.357; 95% CI 0.845–2.178). Conclusions. The observed differences represent a non-significant trend and do not demonstrate a statistically confirmed association between the rs3903239 polymorphism of the PRRX1 gene and AF in the Kazakh population.
Taizhanova et al. (Tue,) reported a other. Patients with atrial fibrillation showed a higher frequency of the rare G allele (AG + GG genotypes) compared to controls, but this difference was not statistically significant (OR 1.357).