Proteins and lunasin from Glycine soja inhibited inflammation by activating the Hippo pathway through phosphorylation of YAP1 kinase

Key Points

• To explore and compare the anti-inflammatory mechanisms of proteins and lunasin from Glycine soja through the Hippo pathway.
• Utilized digested whole flour from Glycine soja
• Measured activation of the Hippo pathway
• Assessed phosphorylation levels of YAP1 kinase
• Activated Hippo pathway demonstrated significant inhibition of inflammation
• Phosphorylation of YAP1 kinase was enhanced
• Potential implications for anti-cancer and anti-inflammatory therapies are indicated.