Findings demonstrate estradiol's role in regulating sleep-wake behaviors in female rats, suggesting therapeutic targets for sleep disorders.
The MnPO is a critical site where E2 regulates sleep-wake behavior. These findings provide a neurobiological framework for understanding how ovarian hormones contribute to sleep disruptions in women, offering potential therapeutic targets for sleep disorders related to hormonal changes.
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Kruk et al. (2026) studied this question.
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