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January 14, 2026Journal of Clinical Ultrasound0 citations

Diagnostic Value of Percutaneous Ultrasound‐Guided Core Needle Biopsy for Pancreatic Lesions: A Retrospective Study of 796 Cases

RBRui BaoChinese PLA General Hospital WLW. LiChinese PLA General Hospital YLY. LuoChinese PLA General Hospital

Key Points

Evaluate the efficacy and safety of percutaneous ultrasound-guided core needle biopsy for diagnosing pancreatic lesions.
Retrospective analysis of patients undergoing percutaneous US-CNB from 2016 to 2025.
Recorded clinical, imaging, and biopsy-related data.
Calculated sensitivity, specificity, accuracy, and predictive values based on surgical findings or clinical diagnoses.
Conducted univariate and logistic regression analyses to identify influencing factors.
Sensitivity: 94.99%, specificity: 92.37%, accuracy: 94.60%, PPV: 98.62%, NPV: 76.22%.
Biopsy results were consistent with final diagnoses in 753 out of 796 cases.
Mild complications occurred in 1.00% of cases, severe complications in 0.88% of cases, both resolved with treatment or on their own.
Location of lesion was identified as an independent factor affecting diagnostic efficacy.

Abstract

ABSTRACT Background The incidence of pancreatic lesions is increasing. However, there was limited study on the efficacy and safety of percutaneous ultrasound‐guided core needle biopsy (US‐CNB) for diagnosing pancreatic lesions. Aims This study aimed to evaluate the efficacy and safety of percutaneous US‐CNB for diagnosing pancreatic lesions and to analyze the influencing factors. Methods Patients who underwent percutaneous US‐CNB for pancreatic lesions from 2016 to 2025 were retrospectively analyzed, and their clinical, imaging, pancreatic biopsy‐related data and pathological diagnosis were recorded; subsequently, 777 patients were included. The sensitivity, specificity, accuracy, positive predictive value (PPV), negative predictive value (NPV) of percutaneous US‐CNB for diagnosing pancreatic lesions were calculated using surgical pathological findings or clinical diagnoses as the gold standard. Factors affecting accuracy were screened using univariate and logistic regression analyses. Results In total, 796 ultrasound‐guided biopsies were successfully performed in 777 patients. Biopsy results were consistent with the final diagnosis in 753 cases (consistent group) and inconsistent in 43 cases (inconsistent group). The sensitivity, specificity, accuracy, PPV, and NPV were 94.99% (644/678), 92.37% (109/118), 94.60% (753/796), 98.62% (644/653), and 76.22% (109/143), respectively. Mild complications occurred in eight cases (8/796, 1.00%), and severe complications, in seven cases (7/796, 0.88%), which resolved on their own or with treatment. The tumor markers, location of lesion for biopsy, and longest diameter of the lesion were significant factors between groups ( p < 0.05). Multivariate regression analysis showed that lesion location ( p = 0.018) was an independent factor affecting diagnostic efficacy. Conclusion Percutaneous US‐CNB is safe and reliable for diagnosing pancreatic lesions, and its accuracy is better for diagnosing pancreatic body and tail lesions.

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