Abstract In each wave, only a small portion of primordial follicles are selectively activated into the growing follicular pool, and the majority of primordial follicles remain in a relatively quiescent state. Hypoxanthine is present in the follicular fluid with high concentrations and inhibits phosphodiesterase (PDE) activity. contribute to the promotion of the cyclic activation of primordial follicles.
Wei et al. (Sat,) studied this question.