What question did this study set out to answer?

To investigate the relationship between hypothyroidism and the risk of intrahepatic cholestasis of pregnancy (ICP).

January 14, 2026Journal of Global Health0 citationsOpen Access

The impact of hypothyroidism on the risk of intrahepatic cholestasis of pregnancy: a large-scale study based on pregnant women with hypothyroidism in Shanghai, China

Key Points

To investigate the relationship between hypothyroidism and the risk of intrahepatic cholestasis of pregnancy (ICP).
Large-scale observational study
Analysis of pregnant women with hypothyroidism
Evaluation of thyroid hormone levels (TSH, FT4)
Assessment of ICP prevalence
Hypothyroidism significantly correlates with increased risk of ICP
TPOAb(+) hypothyroidism shows greater risk for early and severe ICP
ICP prevalence rises with higher TSH and lower FT4 levels

Abstract

We found that CH was significantly associated with a greater risk of ICP. CH, especially TPOAb(+) CH, is associated with a greater risk of both early and severe ICP. Furthermore, the prevalence of ICP increases with increasing TSH and decreasing FT4.

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Cite This Study

Lv et al. (Mon,) studied this question.

synapsesocial.com/papers/696719b10a9733890c4ee1c0 https://doi.org/https://doi.org/10.7189/jogh.16.04013

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