What question did this study set out to answer?

To evaluate the association between plasma 25-hydroxyvitamin D [25(OH)D] concentration and the risk of islet autoimmunity, and to assess whether vitamin D pathway gene polymorphisms modify this relationship.

October 23, 2017DiabetesOpen Access

Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity

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Authors

JNJill M. NorrisUniversity of Colorado Anschutz Medical Campus HLHye Seung LeeSeoul National University BFBrittni N. FrederiksenKaiser Family Foundation

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Implication

Nested case-control study reveals higher childhood 25(OH)D levels reduce islet autoimmunity risk in genetically predisposed children, suggesting protective gene-nutrient interactions.

Key Points

To evaluate the association between plasma 25-hydroxyvitamin D [25(OH)D] concentration and the risk of islet autoimmunity, and to assess whether vitamin D pathway gene polymorphisms modify this relationship.
Conducted a risk set sampled nested case-control study embedded within a prospective cohort of 8,676 children at high genetic risk for type 1 diabetes across six sites in the U.S. and Europe.
Identified 376 case subjects with islet autoimmunity (positive for GADA, IAA, or IA-2A on at least two visits) matched with up to 3 control subjects per case.
Quantified longitudinal 25(OH)D concentrations up to seroconversion and analyzed nine polymorphisms within VDR, CYP24A, CYP27B1, GC, and RXRA as potential effect modifiers.
Higher childhood 25(OH)D concentration was associated with a reduced risk of islet autoimmunity (OR = 0.93 per 5 nmol/L difference; 95% CI 0.89, 0.97) after adjustment for HLA-DR-DQ and ancestry.
The protective effect of 25(OH)D was significantly modified by the VDR rs7975232 polymorphism (interaction P = 0.0072), with per-5 nmol/L ORs of 1.00 (95% CI 0.93, 1.07) for 0 minor alleles, 0.92 (95% CI 0.89, 0.96) for 1 minor allele, and 0.86 (95% CI 0.80, 0.92) for 2 minor alleles.

Cite This Study

Norris et al. (2017) studied this question.

synapsesocial.com/papers/69691d95ec6eed3c34f533b3 https://doi.org/10.2337/db17-0802

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Implication

Nested case-control study reveals higher childhood 25(OH)D levels reduce islet autoimmunity risk in genetically predisposed children, suggesting protective gene-nutrient interactions.

Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity

Discussion

Member takes

Implication

Key Points

Cite This Study

Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity

Discussion

Member takes

Implication

Key Points

Cite This Study

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