Key result
TAVR is appropriate for very high surgical risk patients with severe AS.
Aortic-valve replacement is the only effective therapy for progressive aortic-valve stenosis, with transcatheter replacement being appropriate for patients at very high surgical risk.
Supports TAVR for very high-risk severe AS; leaves open need for randomized data in lower-risk groups.
Aortic-valve stenosis is a progressive condition; end-stage disease leads to death due to obstruction of left ventricular outflow. Aortic-valve replacement is the only effective therapy. Transcatheter aortic-valve replacement is appropriate in patients at very high surgical risk.
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Otto et al. (2014) studied this question. Transcatheter aortic-valve replacement is appropriate for very high surgical risk patients with severe aortic-valve stenosis.
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