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Demonstrates efficient hydrofunctionalization of alkynes in water using a gold(I) complex, indicating its potential for green chemistry.
Thiamine diphosphate (ThDP), or cocarboxylase, is an enzyme cofactor that catalyzes crucial metabolic reactions via a thiazolium carbene in all living systems. In this study, we successfully exploit this N ‐heterocyclic carbene ligand for the efficient synthesis of a monodentate gold (I) complex. The resulting ThDP = AuCl complex efficiently catalyzes intramolecular hydroamination, hydroalkoxylation, and hydrocarboxylation of a diverse array of alkyne substrates in water and open air at mild temperatures. This new metal catalyst is environmentally friendly and holds promise for the construction of novel artificial metalloenzymes.
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Dai et al. (2026) studied this question.
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