ABSTRACT An enantiodivergent route was devised for accessing the two enantiomers of indolo2,3‐aquinolizidine, which serve as a platform for the synthesis of Corynanthe alkaloids with dimorphic configurations at the C3 position. The cascade process, involving dipolar cycloaddition, N–O bond cleavage, and cyclization, minimizes the need for functional group elaboration. Subsequent alkylation, allylation, and ring‐closing metathesis smoothly constructed the pentacyclic ring system embedded in yohimbine alkaloids. The inherent simplicity and efficiency of enzymatic kinetic resolution prove valuable for diverse structural derivatives.
Wu et al. (Thu,) studied this question.
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