After 6 months of chemotherapy, a 24-year-old male with sudden sensorineural hearing loss due to Langerhans cell histiocytosis showed no change in hearing levels.
Case Report (n=1)
Langerhans cell histiocytosis should be considered as a potential cause of sudden sensorineural hearing loss, especially when accompanied by other paraneoplastic conditions like diabetes insipidus.
Sudden sensorineural hearing loss is a condition marked by a rapid decline in hearing, defined as a decrease of 30 dB or more across three adjacent audiometric frequencies within 72 h. It can result from various factors, including ischemic events, infections, or tumors like meningioma and schwannoma, and in rare cases, may be linked to Langerhans histiocytosis, which involves an accumulation of specific immune cells. This document reviews literature and presents a case study of a 24-year-old male from Iran diagnosed with sudden sensorineural hearing loss due to Langerhans cell histiocytosis. The patient, who had diabetes insipidus, showed eosinophil-rich lesions with CD1a-positive, S100-positive, and Cyclin D1-positive cells. After 6 months of chemotherapy, there was no change in hearing levels. This case report underscores the importance of considering an occupying lesion in cases of sensorineural hearing loss, particularly when there are indications of additional paraneoplastic conditions.
Davoodi et al. (Thu,) conducted a case report in Sudden sensorineural hearing loss due to Langerhans cell histiocytosis (n=1). Chemotherapy was evaluated on Hearing levels. After 6 months of chemotherapy, a 24-year-old male with sudden sensorineural hearing loss due to Langerhans cell histiocytosis showed no change in hearing levels.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: