ABSTRACT In a patient with genetically confirmed SPG4–linked hereditary spastic paraplegia, initiation of allopurinol for asymptomatic hyperuricemia led to rapid and sustained improvement in lower limb spasticity, allowing marked reduction of antispasmodic therapy. This serendipitous finding suggests a potential therapeutic role of xanthine oxidase inhibition in managing HSP‐related spasticity.
Elmezayen et al. (Thu,) studied this question.