Latent class analysis of substance use behaviors and associations of class membership with gender affirmation, social determinants of health, and HIV-status among transfeminine adults in the Eastern and Southern United States

Key Points

• The aim is to explore substance use behaviors in transfeminine adults and how these relate to gender affirmation and social determinants of health.
• Conducted latent class analysis to identify substance use behaviors among transfeminine adults.
• Examined associations between class membership, gender affirmation, socioeconomic conditions, and HIV-status.
• Included adults from the Eastern and Southern United States.
• Higher socioeconomic conditions correlated with lower alcohol misuse and polysubstance use.
• Medical gender affirmation needs linked to improved substance use outcomes.
• Class memberships varied significantly by gender affirmation and social determinants.