Facile synthesis of zeolitic imidazolate framework coated glass microspheres

Q: What is the clinical evidence from this study?

Population: Drug delivery. Intervention: ZIF-8-coated phosphate-based glass microspheres vs. Pristine phosphate-based glass microspheres. Primary outcome: Mass loss percentage after 30 days in water degradation study.

Ashleigh M. Chester; Celia Castillo Blas; Luke Woodliffe; Towhid Islam; Jesús Molinar-Díaz; Andi Arjuna; Emma R. Barney; Ifty Ahmed; Andrea Laybourn; David A. Keen; Thomas D. Bennett

doi:10.1039/d5tb02418h

January 1, 2026Journal of Materials Chemistry BOpen Access

Facile synthesis of zeolitic imidazolate framework coated glass microspheres

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Key Points

The aim is to develop a straightforward method for creating ZIF-8 coatings on glass microspheres.
One-step synthetic methodology used for fabrication.
Room temperature conditions maintained throughout the process.
In situ growth of ZIF-8 on phosphate-based glass microspheres.
ZIF-8 effectively coated both solid and porous glass microspheres.
The synthesis process is efficient and reproducible.

PICO

P

Population

Drug delivery

I

Intervention / Comparator

ZIF-8-coated phosphate-based glass microspheres vs Pristine phosphate-based glass microspheres

O

Primary Outcome

Mass loss percentage after 30 days in water degradation study

Main Result

Absolute Event Rate: 48% vs 70%

Limitations

Lack of statistical analysis for effect sizes
No specific age or gender demographics provided for participants
No data on long-term stability or clinical implications of the ZIF-8 coating effects on various biological responses.

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Implication

Study demonstrates the fabrication of ZIF-8-coated microspheres, suggesting a novel synthesis approach.

Abstract

In this study we report a facile one-step, room temperature (RT) synthetic methodology for fabricating ZIF-8-coated phosphate-based glass (PBG) microspheres. ZIF-8 was grown in situ onto solid (non-porous) and porous...

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Cite This Study

Chester et al. (2026) studied Drug delivery. ZIF-8-coated phosphate-based glass microspheres vs. Pristine phosphate-based glass microspheres was evaluated on Mass loss percentage after 30 days in water degradation study.

synapsesocial.com/papers/6969d4a2940543b977709808 https://doi.org/10.1039/d5tb02418h

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Facile synthesis of zeolitic imidazolate framework coated glass microspheres

Key Points

PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Facile synthesis of zeolitic imidazolate framework coated glass microspheres

Key Points

PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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