What question did this study set out to answer?

The aim is to develop a straightforward method for creating ZIF-8 coatings on glass microspheres.

January 16, 2026Journal of Materials Chemistry B0 citationsOpen Access

Facile synthesis of zeolitic imidazolate framework coated glass microspheres

Q: What is the clinical evidence from this study?

Study design: Other. Population: Drug delivery. Intervention: ZIF-8-coated phosphate-based glass microspheres vs. Pristine phosphate-based glass microspheres. Primary outcome: Mass loss percentage after 30 days in water degradation study.

ACAshleigh M. ChesterUniversity of Cambridge CBCelia Castillo BlasUniversity of Cambridge LWLuke Woodliffe

Key Result

ZIF-8 coating significantly reduced mass loss of the microspheres in degradation studies, indicating a protective effect against degradation in aqueous environments.

Key Points

The aim is to develop a straightforward method for creating ZIF-8 coatings on glass microspheres.
One-step synthetic methodology used for fabrication.
Room temperature conditions maintained throughout the process.
In situ growth of ZIF-8 on phosphate-based glass microspheres.
ZIF-8 effectively coated both solid and porous glass microspheres.
The synthesis process is efficient and reproducible.

PICO

Population

Drug delivery

Intervention / Comparator

ZIF-8-coated phosphate-based glass microspheres vs Pristine phosphate-based glass microspheres

Primary Outcome

Mass loss percentage after 30 days in water degradation study

Main Result

Absolute Event Rate: 48% vs 70%

Limitations

Lack of statistical analysis for effect sizes
No specific age or gender demographics provided for participants
No data on long-term stability or clinical implications of the ZIF-8 coating effects on various biological responses.

Abstract

In this study we report a facile one-step, room temperature (RT) synthetic methodology for fabricating ZIF-8-coated phosphate-based glass (PBG) microspheres. ZIF-8 was grown in situ onto solid (non-porous) and porous...

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Cite This Study

Chester et al. (Thu,) conducted a other in Drug delivery. ZIF-8-coated phosphate-based glass microspheres vs. Pristine phosphate-based glass microspheres was evaluated on Mass loss percentage after 30 days in water degradation study. ZIF-8 coating significantly reduced mass loss of the microspheres in degradation studies, indicating a protective effect against degradation in aqueous environments.

synapsesocial.com/papers/6969d4a2940543b977709808 https://doi.org/https://doi.org/10.1039/d5tb02418h