Oxidative nucleophilic addition of amide enolates to π-deficient aromatic and heteroaromatic ring systems

Key Points

• The research aims to explore the nucleophilic addition of amide enolates to various π-deficient aromatic and heteroaromatic systems.
• Utilized lactam enolates for nucleophilic addition.
• Investigated π-deficient aromatic and heteroaromatic ring systems.
• Employed spirocyclisation technique for structural complexity.
• Successfully delivered complex structures from accessible starting materials.
• Demonstrated effective transformations involving the targeted nucleophilic addition.