An integrative chemical and genomic similarity approach linking fungal secondary metabolites and biosynthetic gene clusters

Karin Steffen; Manuel Rangel‐Grimaldo; Thomas J. C. Sauters; David C. Rinker; Huzefa A. Raja; Tyler Graf; Adiyantara Gumilang; Olivia L. Riedling; Gustavo Goldman; Nicholas H. Oberlies; Antonis Rokas

doi:10.1039/d5ob01965f

January 1, 2025Organic & Biomolecular ChemistryOpen Access

An integrative chemical and genomic similarity approach linking fungal secondary metabolites and biosynthetic gene clusters

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Key Points

The aim is to connect fungal secondary metabolites (SMs) with their corresponding biosynthetic gene clusters (BGCs) based on chemical and genomic similarities.
Utilized integrative approaches to analyze chemical structures and genomic data.
Examined the relationship between SMs and BGCs from various fungal species.
Conducted comparative analyses to identify connections.
Establishes clear links between specific SMs and their BGCs.
Identifies potential pathways for exploring the bioactivities of fungal metabolites.
Demonstrates that genomic data can enhance understanding of SM production.

Implication

Integrative analysis links secondary metabolites to biosynthetic gene clusters in fungi, suggesting new avenues for bioactivity exploration.

Abstract

Fungi are well known to biosynthesize structurally complex secondary metabolites (SMs) with diverse bioactivities. These fungal SMs are frequently produced by biosynthetic gene clusters (BGCs). Linking SMs to their BGCs...

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Cite This Study

Steffen et al. (2025) studied this question.

synapsesocial.com/papers/6969d4c3940543b977709a68 https://doi.org/10.1039/d5ob01965f

View Full Paper

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An integrative chemical and genomic similarity approach linking fungal secondary metabolites and biosynthetic gene clusters

Key Points

Implication

Abstract

Discussion

Cite This Study

An integrative chemical and genomic similarity approach linking fungal secondary metabolites and biosynthetic gene clusters

Key Points

Implication

Abstract

Discussion

Cite This Study

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