What question did this study set out to answer?

The research aims to develop a nanodrug that enhances drug delivery and treatment efficacy for breast cancer.

January 16, 2026Open Access

Hyaluronan like polysaccharide based nanodrugs with enhanced CD44 avidity for image-guided drug delivery to breast cancer

CYChia-Wei YangMichigan State University AUA. K. M. Atique UllahMichigan State University ZWZhen WangShanghai University of Engineering Science

Key Points

The research aims to develop a nanodrug that enhances drug delivery and treatment efficacy for breast cancer.
Synthesis of a new hyaluronan derivative with enhanced CD44 affinity.
Combination of salinomycin and indocyanine green in the nanodrug.
Assessment of treatment efficacy using a mouse model of breast cancer.
The nanodrug significantly enhances treatment efficacy against breast cancer.
Improved targeting of cancer cells via enhanced CD44 affinity.

Abstract

A theranostic nanodrug synthesized with a new hyaluronan derivative with enhanced CD44 affinity, salinomycin, and indocyanine green, has been shown to significantly enhance the treatment efficacy against breast cancer in a mouse model.

问 AI

Bookmark

View Full Paper