What is the clinical evidence from this study?

Study design: Cohort. Population: severe aortic stenosis (n=429). Intervention: BUN/EF ratio (baseline and 48-72 h). Primary outcome: long-term all-cause mortality (HR 3.46, p=<0.001).

What does this research mean for the field?

The 48–72 h BUN/EF ratio independently predicts in-hospital mortality after TAVR with an HR of 3.79 per 1 SD increase, demonstrating superior discrimination (AUC = 0.826). Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

This study evaluates how effectively the BUN/EF ratio can predict mortality following transcatheter aortic valve replacement (TAVR).

January 16, 2026Journal of Clinical MedicineOpen Access

Temporal Cardiorenal Dynamics and Mortality Prediction After TAVR: The Prognostic Value of the 48–72 h BUN/EF Ratio

Q: What are the key findings of this study?

Baseline and 48-72 h BUN/EF ratios were independently associated with long-term all-cause mortality after TAVR (HR 3.46 and 3.79 per 1 SD increase, respectively; both p<0.001).

Q: What does this research mean for the field?

The 48–72 h BUN/EF ratio independently predicts in-hospital mortality after TAVR with an HR of 3.79 per 1 SD increase, demonstrating superior discrimination (AUC = 0.826). Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

Q: What question did this study set out to answer?

This study evaluates how effectively the BUN/EF ratio can predict mortality following transcatheter aortic valve replacement (TAVR).

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Key result

Higher 48-72 h BUN/EF ratio predicts ~279% greater in-hospital mortality risk per SD after TAVR.

HR 3.46
P<0.001
n=429

Why the study?

Renal and cardiac dysfunction determine adverse outcomes after TAVR, but the prognostic value of baseline and temporal 48-72 h BUN/EF ratios for predicting mortality had not been evaluated.

Does the baseline and 48-72 h BUN/EF ratio predict mortality in patients undergoing TAVR for severe aortic stenosis?

Population

429 patients who underwent TAVR for severe aortic stenosis

Comparison

Baseline vs temporal (48-72 h) BUN/EF ratios

Design

Retrospective cohort study

Follow-up

Median 733 days

Authors

AÇAykan ÇelikIzmir Kâtip Çelebi University TKTuncay KırışIzmir Kâtip Çelebi University FEFatma EsinIzmir Kâtip Çelebi University

Discussion

Member takes

Implication

The 48–72 h BUN/EF ratio was associated with post-TAVR mortality; leaves open whether it improves risk stratification in prospective cohorts.

Key Points

This study evaluates how effectively the BUN/EF ratio can predict mortality following transcatheter aortic valve replacement (TAVR).
Retrospective analysis of 429 TAVR patients from 2017 to 2025
Assessment of baseline and 48–72 h BUN/EF ratios
Use of ROC curves, Cox regression, and reclassification metrics for analysis
Median follow-up of 733 days to monitor mortality outcomes
Overall mortality rate was 37.8% with in-hospital mortality at 7.9%
Both BUN/EF ratios were significantly predictive of mortality (HR = 3.46 and 3.79; p < 0.001)
The temporal BUN/EF ratio showed higher predictive accuracy for in-hospital mortality (AUC = 0.826)
Integrating baseline BUN/EF into EuroSCORE II improved predictive performance (AUC 0.712)

Study Design

Type

Cohort (n=429)

Structured PICO

Does the baseline and 48-72 h BUN/EF ratio predict mortality in patients undergoing TAVR for severe aortic stenosis?

Population

429 patients (mean age 76 years, 51% female) undergoing TAVR for severe aortic stenosis, followed for a median of 733 days.

Exposure

Measurement of baseline and temporal (48–72 h) blood urea nitrogen to left ventricular ejection fraction (BUN/EF) ratio

Outcome

Long-term all-cause mortalityhard clinical

Main Result

Hazard Ratio: 3.46

p-value: p=<0.001

The BUN/EF ratio, particularly measured at 48-72 hours post-procedure, is a strong independent predictor of early and long-term mortality after TAVR, improving risk stratification beyond the EuroSCORE II.

Cite This Study

Çelik et al. (2026) conducted a cohort in severe aortic stenosis (n=429). BUN/EF ratio (baseline and 48-72 h) was evaluated on long-term all-cause mortality (HR 3.46, p=<0.001). Baseline and 48-72 h BUN/EF ratios were independently associated with long-term all-cause mortality after TAVR (HR 3.46 and 3.79 per 1 SD increase, respectively; both p<0.001).

synapsesocial.com/papers/6969d4fd940543b977709ef7 https://doi.org/10.3390/jcm15020676

Topics

TAVR in low-risk patients Transcatheter aortic valve replacement

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January 16, 2026Journal of Clinical MedicineOpen Access

Temporal Cardiorenal Dynamics and Mortality Prediction After TAVR: The Prognostic Value of the 48–72 h BUN/EF Ratio

View Full Paper

Ask AI

Bookmark

Key result

Higher 48-72 h BUN/EF ratio predicts ~279% greater in-hospital mortality risk per SD after TAVR.

HR 3.46
P<0.001
n=429

Why the study?

Renal and cardiac dysfunction determine adverse outcomes after TAVR, but the prognostic value of baseline and temporal 48-72 h BUN/EF ratios for predicting mortality had not been evaluated.

Does the baseline and 48-72 h BUN/EF ratio predict mortality in patients undergoing TAVR for severe aortic stenosis?

Population

429 patients who underwent TAVR for severe aortic stenosis

Comparison

Baseline vs temporal (48-72 h) BUN/EF ratios

Design

Retrospective cohort study

Follow-up

Median 733 days

Authors

AÇAykan ÇelikIzmir Kâtip Çelebi University TKTuncay KırışIzmir Kâtip Çelebi University FEFatma EsinIzmir Kâtip Çelebi University

Discussion

Member takes

Implication

The 48–72 h BUN/EF ratio was associated with post-TAVR mortality; leaves open whether it improves risk stratification in prospective cohorts.

Key Points

This study evaluates how effectively the BUN/EF ratio can predict mortality following transcatheter aortic valve replacement (TAVR).
Retrospective analysis of 429 TAVR patients from 2017 to 2025
Assessment of baseline and 48–72 h BUN/EF ratios
Use of ROC curves, Cox regression, and reclassification metrics for analysis
Median follow-up of 733 days to monitor mortality outcomes
Overall mortality rate was 37.8% with in-hospital mortality at 7.9%
Both BUN/EF ratios were significantly predictive of mortality (HR = 3.46 and 3.79; p < 0.001)
The temporal BUN/EF ratio showed higher predictive accuracy for in-hospital mortality (AUC = 0.826)
Integrating baseline BUN/EF into EuroSCORE II improved predictive performance (AUC 0.712)

Study Design

Type

Cohort (n=429)

Structured PICO

Does the baseline and 48-72 h BUN/EF ratio predict mortality in patients undergoing TAVR for severe aortic stenosis?

Population

429 patients (mean age 76 years, 51% female) undergoing TAVR for severe aortic stenosis, followed for a median of 733 days.

Exposure

Measurement of baseline and temporal (48–72 h) blood urea nitrogen to left ventricular ejection fraction (BUN/EF) ratio

Outcome

Long-term all-cause mortalityhard clinical

Main Result

Hazard Ratio: 3.46

p-value: p=<0.001

Cite This Study

synapsesocial.com/papers/6969d4fd940543b977709ef7 https://doi.org/10.3390/jcm15020676

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

TAVR in low-risk patients Transcatheter aortic valve replacement

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