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The aim is to create a detailed transcriptome and proteome map of various primary human cell types.

January 16, 2026Nucleic Acids ResearchOpen Access

A transcriptomic and proteomic map of primary human cell types

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Comprehensive mapping reveals cell type-specific molecular cues, highlighting insights into disease mechanisms.

The aim is to create a detailed transcriptome and proteome map of various primary human cell types.
Analyzed 28 primary human cell types using transcriptomic and proteomic profiling.
Identified clusters of epithelial, endothelial, and mesenchymal cell types.
Utilized immunohistochemistry to validate specific proteins across human tissues.
Conducted extensive protein database searches for post-translational modifications (PTMs).
Explored alternative translational start sites and splice junctions for genome annotation.
Identified cell type-enriched molecules such as GRAP and C1orf116.
Discovered novel PTMs, including serine O-acetylation and histidine methylation.
Observed higher frequency of dioxidation on tryptophan than on methionine.
Detected peptides supporting translational readthrough for proteins like LDHB and MDH1.
Revealed significant molecular heterogeneity among primary human cell types.

Mun et al. (2025) studied this question.

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January 16, 2026Nucleic Acids ResearchOpen Access

View Full Paper

Ask AI

Bookmark

Authors

Comprehensive mapping reveals cell type-specific molecular cues, highlighting insights into disease mechanisms.

The aim is to create a detailed transcriptome and proteome map of various primary human cell types.
Analyzed 28 primary human cell types using transcriptomic and proteomic profiling.
Identified clusters of epithelial, endothelial, and mesenchymal cell types.
Utilized immunohistochemistry to validate specific proteins across human tissues.
Conducted extensive protein database searches for post-translational modifications (PTMs).
Explored alternative translational start sites and splice junctions for genome annotation.
Identified cell type-enriched molecules such as GRAP and C1orf116.
Discovered novel PTMs, including serine O-acetylation and histidine methylation.
Observed higher frequency of dioxidation on tryptophan than on methionine.
Detected peptides supporting translational readthrough for proteins like LDHB and MDH1.
Revealed significant molecular heterogeneity among primary human cell types.

Mun et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark