Key result
Men with spontaneous coronary artery dissection were significantly younger and had more cardiovascular risk factors than women, with a higher representation of angiographic types 1 and 1/2.
Why the study?
SCAD is an increasingly recognized cause of ACS, mostly in women, but differences between the sexes remained to be investigated.
Do clinical and angiographic characteristics differ between men and women with spontaneous coronary artery dissection?
Do clinical and angiographic characteristics differ between men and women with spontaneous coronary artery dissection?
Men with SCAD present at a younger age with more cardiovascular risk factors and a higher prevalence of intimal tear angiographic patterns compared to women, suggesting potential sex-related mechanistic differences.
Background: Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of acute coronary syndrome, mostly in women; however, differences between the sexes should be investigated. Materials & methods: Hundred consecutive patients affected by SCAD were identified; coronary lesions were classified according to the most recent classification and clinical and angiographic data of men and women were compared. Results: Men were significantly younger than women, with more cardiovascular risk factors. Lesions were prevalently classified as type 2A, type 2B or type 1; an angiographic pattern compatible with the presence of an intimal tear (types 1 and 1/2) was more represented in males. Conclusion: Sex-related differences in clinical and angiographic characteristics could help in shedding light on mechanisms that contribute to SCAD.
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Zilio et al. (2020) studied this question. Men with spontaneous coronary artery dissection were significantly younger and had more cardiovascular risk factors than women, with a higher representation of angiographic types 1 and 1/2.
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