What are the key findings of this study?

In patients with EF 60 ml/min/1.73 m2.

What does this research mean for the field?

In patients with EF 60 ml/min/1.73 m2. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

To investigate how ejection fraction relates to long-term outcomes for patients with varying renal function after acute coronary syndrome.

January 17, 2026Russian Cardiology Bulletin0 citationsOpen Access

Ejection fraction and long-term outcomes in patients with different renal function after acute coronary syndrome

ASA.M. ShchinovaNational Medical Research Center of Cardiology APA.V. PotekhinaNational Medical Research Center of Cardiology ISI.I. ShestovaGuz "Tul'skiy Oblastnoy Onkologicheskiy Dispanser

Key Result

In patients with EF<50% and GFR<60 ml/min/1.73 m2, all-cause mortality is 5.2 times and cardiovascular mortality 7.18 times higher than those with GFR>60 ml/min/1.73 m2.

Key Points

To investigate how ejection fraction relates to long-term outcomes for patients with varying renal function after acute coronary syndrome.
Analyzed data from 1,607 patients with acute coronary syndrome discharged between 2019-2020.
Measured left ventricular ejection fraction (LVEF) and mortality rates after treatment.
Divided patients based on renal function: CKD≥C3a and GFR>60 ml/min/1.73 m2.
EF increased 1.1% in CKD≥C3a patients and 7.1% in patients with GFR>60 ml/min/1.73 m2.
Risk of all-cause mortality was 5.2 times higher for CKD patients with EF<50% compared to those with GFR>60 ml/min/1.73 m2.
Cardiovascular mortality was 7.18 times higher in CKD patients with EF<50% than in GFR>60 ml/min/1.73 m2.

Structured PICO

How does renal function impact LVEF recovery and long-term mortality in patients following acute coronary syndrome?

Population

1,607 patients with acute coronary syndrome (ACS), mean age 63.8±12.1 years, 64.9% men.

Outcome

Left ventricular ejection fraction (LVEF) change within a year, all-cause mortality, and cardiovascular mortalityhard clinical

In patients post-ACS, those with CKD≥C3a do not show significant LVEF improvement within a year and have markedly higher all-cause and cardiovascular mortality compared to those with preserved renal function, regardless of baseline LVEF.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Objective. To analyze ejection fraction depending on renal function and its relationship with long-term outcomes in patients with acute coronary syndrome. Material and methods. The study included 1.607 patients (mean age 63.8±12.1 years, 64.9% men) discharged between January 1, 2019, and December 31, 2020. All ones underwent treatment for ACS. The authors analyzed left ventricular ejection fraction (LVEF), all-cause and cardiovascular mortality in patients with CKD≥C3a and without significant renal impairment. The median follow-up was 42.3 32.5; 48.4 months. Results. In patients with CKD≥C3a, EF increased only by 1.1% -4.8; 11 (p=0.07) within a year, in patients with GFR>60 ml/min/1.73 m2 — by 7.1% 0.4; 14.1 (p60 ml/min/1.73 m2. All-cause mortality rate in patients with preserved LVEF was 6.53 times (95% CI 2.94—14.51) higher and cardiovascular mortality rate was 6.91 times (95% CI 2.34—20.4) higher in patients with GFR60 ml/min/1.73 m2. Conclusion. In patients with CKD≥C3a, LVEF does not significantly increase within a year after ACS. All-cause and cardiovascular mortality rate in patients with CKD≥C3a and different LVEFs are comparable, whereas these values increase inversely proportional to EF decrease in patients without severe renal impairment.

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