What is the clinical evidence from this study?

Study design: Review. Population: Prediabetes. Intervention: Intensive lifestyle intervention and metformin.

What question did this study set out to answer?

The aim is to assess whether prediabetes should be recognized as a treatable disease due to its significant health implications.

January 17, 2026Journal of Clinical MedicineOpen Access

Should Prediabetes Be Classified as a Treatable Disease?

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Key result

Prediabetes, affecting approximately 21% of the global population, should be classified as a treatable disease due to its cardiovascular risks and the efficacy of intensive lifestyle interventions.

Key Points

The aim is to assess whether prediabetes should be recognized as a treatable disease due to its significant health implications.
Review of global prevalence and complications related to prediabetes
Discussion on diagnosis methods including plasma glucose and HbA1c
Examination of intensive lifestyle interventions and metformin therapy
Consideration of high-risk groups for targeted therapy
Approximate 21% of the global population is affected by prediabetes.
Intensive lifestyle interventions have shown to reduce the progression to type 2 diabetes significantly.
Metformin therapy effectively prevents the progression to type 2 diabetes.
Serious consideration for classification of prediabetes as a disease is advised.

Structured PICO

Population

Persons with prediabetes, especially those at high risk for type 2 diabetes mellitus (T2DM) such as those with impaired glucose tolerance (IGT), impaired fasting glucose (IFG) ≥ 110 mg/dL (6.1 mmol/L), and/or HbA1c ≥ 6.0% (42 mmol/mol) coupled with overweightness or obesity.

Intervention

Intensive lifestyle (ILS) intervention (calorie reduction, 150 min/week physical activity, targeting ≥5% weight loss) and/or metformin therapy

Discussion

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Implication

Classifying prediabetes as a treatable disease could promote early intervention with intensive lifestyle changes and metformin, potentially reducing the global burden of type 2 diabetes and cardiovascular disease.

Cite This Study

We et al. (2026) conducted a review in Prediabetes. Intensive lifestyle intervention and metformin was evaluated. Prediabetes, affecting approximately 21% of the global population, should be classified as a treatable disease due to its cardiovascular risks and the efficacy of intensive lifestyle interventions.

synapsesocial.com/papers/696b25cfd2a12237a9349178 https://doi.org/10.3390/jcm15020710

View Full Paper

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Should Prediabetes Be Classified as a Treatable Disease?

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Should Prediabetes Be Classified as a Treatable Disease?

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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