What question did this study set out to answer?

To evaluate the efficacy of high-dose corticosteroid therapy in cases of acute severe nickel carbonyl poisoning.

January 17, 2026BMC Pulmonary Medicine0 citationsOpen Access

High-dose corticosteroid application in acute severe nickel carbonyl poisoning: a case series of three occupational exposures and their recovery outcomes

YCYixin ChenJilin University ZYZhuo YangJilin University YXYuqi XiaoJilin University

Key Points

To evaluate the efficacy of high-dose corticosteroid therapy in cases of acute severe nickel carbonyl poisoning.
Case series of three occupational exposures to nickel carbonyl
Administration of high-dose corticosteroids
Monitoring recovery outcomes and lung health
Prompt corticosteroid therapy improved survival rates in all cases.
Reduction in signs of irreversible lung injury observed in follow-up.
Clinical evidence supports corticosteroid use in similar poisoning scenarios.

Abstract

Nickel carbonyl exposure demanded a high index of suspicion and prompt initiation of high-dose corticosteroid therapy was required to prevent irreversible lung injury and improve survival. This case series provides valuable clinical evidence to inform diagnostic and therapeutic approaches for this rare occupational poisoning.

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