This experiment shows zofenopril improves oxidative status and stabilizes intraocular pressure in glaucoma models, suggesting therapeutic benefits.
Prolonged systemic administration of zofenopril in a rabbit model of glaucoma effectively attenuated oxidative stress and stabilized intraocular pressure. Zofenopril prevented a progressive rise in IOP observed in untreated animals, maintaining IOP values close to physiological levels throughout the experiment. The treatment resulted in a marked decrease in LPO and MDA accumulation within the retina, optic nerve, and drainage zone, along with reduced generation of hydroxyl and superoxide radicals and a significant restoration of antioxidant enzyme activity.
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Mikheytseva et al. (2026) studied this question.
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